Chicken Bubble Biscuit Bake Casserole Recipe
Introduction
Chicken Bubble Biscuit Bake is a comforting and easy-to-make casserole that combines tender chicken, creamy veggies, and fluffy biscuits. Perfect for weeknight dinners, this dish brings together familiar flavors in a warm, cheesy bake that the whole family will enjoy.

Ingredients
- 2 cups cooked chicken (shredded or diced, rotisserie works great)
- 1 10.5 oz can cream of chicken soup (or cream of mushroom)
- 1/2 cup sour cream (or plain Greek yogurt)
- 1/2 cup milk
- 1 cup frozen mixed vegetables (peas, carrots, corn, beans)
- 1 tsp garlic powder
- 1/2 tsp onion powder
- Salt & pepper (to taste)
- 1 16 oz can refrigerated biscuit dough, cut into quarters
- 1 cup shredded cheddar cheese (or mozzarella)
- 1 tbsp melted butter (optional, for brushing)
Instructions
- Step 1: Preheat the oven to 350°F (175°C) and lightly grease a 9×13-inch baking dish.
- Step 2: In a large bowl, combine the cooked chicken, cream of chicken soup, sour cream, milk, frozen mixed vegetables, garlic powder, onion powder, salt, and pepper. Stir until the mixture is smooth and well blended.
- Step 3: Fold the quartered biscuit pieces into the chicken mixture, making sure the biscuits are coated evenly.
- Step 4: Pour the entire mixture into the prepared baking dish and spread it out evenly. Sprinkle the shredded cheddar cheese over the top.
- Step 5: Cover the dish with foil and bake for 20 minutes. Then remove the foil and continue baking for an additional 10 to 15 minutes, or until the biscuits are puffed, golden, and cooked through.
- Step 6: If using, brush the melted butter over the top of the casserole. Let it cool slightly before serving.
Tips & Variations
- Use leftover cooked chicken or rotisserie chicken to save time and add flavor.
- Substitute the mixed vegetables with fresh diced bell peppers or broccoli for a different texture.
- Try different cheeses like Monterey Jack or pepper jack for added spice or creaminess.
- For a lighter version, swap sour cream with plain Greek yogurt and use low-fat biscuits.
Storage
Store any leftover casserole covered in the refrigerator for up to 3 days. To reheat, warm individual portions in the microwave or oven until heated through. For best texture, cover with foil to prevent drying out while reheating in the oven.
How to Serve

Serve this delicious recipe with your favorite sides.
FAQs
Can I make this casserole ahead of time?
Yes, you can assemble the casserole and refrigerate it covered for up to 24 hours before baking. Just add a few extra minutes to the baking time if baking from cold.
Can I use homemade biscuit dough instead of canned?
Absolutely! Homemade biscuit dough works well and adds a fresh, homemade touch. Just cut it into quarters to match the recipe’s proportions.
PrintChicken Bubble Biscuit Bake Casserole Recipe
Chicken Bubble Biscuit Bake Casserole is a comforting and hearty dish featuring tender cooked chicken mixed with creamy soup, sour cream, milk, and mixed vegetables, all combined with fluffy biscuit pieces and topped with melted cheese. Baked until golden and bubbly, this casserole is perfect for a cozy family dinner or potluck.
- Prep Time: 15 minutes
- Cook Time: 35 minutes
- Total Time: 50 minutes
- Yield: 6 servings 1x
- Category: Casserole
- Method: Baking
- Cuisine: American
Ingredients
Chicken Filling
- 2 cups cooked chicken (shredded or diced; rotisserie works great)
- 1 10.5 oz can cream of chicken soup (or cream of mushroom)
- 1/2 cup sour cream (or plain Greek yogurt)
- 1/2 cup milk
- 1 cup frozen mixed vegetables (peas, carrots, corn, beans)
- 1 tsp garlic powder
- 1/2 tsp onion powder
- Salt & pepper to taste
Biscuit Layer & Toppings
- 1 16 oz can refrigerated biscuit dough, cut into quarters
- 1 cup shredded cheddar cheese (or mozzarella)
- 1 tbsp melted butter (optional, for brushing)
Instructions
- Preheat Oven: Preheat your oven to 350°F (175°C) and lightly grease a 9×13-inch baking dish to prepare for the casserole assembly.
- Mix the Filling: In a large mixing bowl, combine the cooked chicken, cream of chicken soup, sour cream, milk, frozen mixed vegetables, garlic powder, onion powder, salt, and pepper. Stir everything together until the mixture is smooth and well incorporated.
- Add Biscuits: Fold in the quartered biscuit dough pieces gently, ensuring they are well coated with the chicken and vegetable mixture without breaking them apart excessively.
- Assemble Casserole: Pour the entire mixture evenly into the prepared baking dish. Evenly sprinkle the shredded cheddar cheese over the top of the casserole to add a melty, cheesy crust.
- Bake Covered: Cover the baking dish with aluminum foil and bake in the preheated oven for 20 minutes, allowing the biscuits to begin cooking and the flavors to meld.
- Bake Uncovered: Remove the foil and continue baking for an additional 10 to 15 minutes, or until the biscuits are puffed up, golden brown, and fully cooked through.
- Finish and Serve: Optionally brush the warm casserole with melted butter for extra richness. Let it cool slightly before serving to set and enhance the flavors.
Notes
- Rotisserie chicken is a quick and flavorful shortcut for the shredded chicken in this recipe.
- You can substitute cream of mushroom soup if you prefer a different flavor base.
- For a lighter option, replace sour cream with plain Greek yogurt.
- Try swapping cheddar cheese for mozzarella or a blend of cheeses for variation.
- Make sure to cut the biscuit dough into quarters to ensure even baking and proper puffing in the casserole.
- Brushing with melted butter at the end adds a lovely sheen and extra buttery taste but is optional.
Keywords: chicken casserole, biscuit bake, comfort food, easy dinner, cheesy chicken bake, one dish meal

